A straightforward approach towards 5-substituted thiazolylpeptides via the thio-Ugi-reaction.
نویسندگان
چکیده
A wide range of 5-substituted thiazoles are easily accessible via cross coupling of thiazolyl triflates. These activated thiazoles can be obtained by Ugi reactions using thioacids (thio-Ugi-reaction) and subsequent cyclisation of the endo thiopeptides formed with triflic anhydride. In addition, cyclisations with acyl halides give rise to 5-acyloxysubstituted derivatives.
منابع مشابه
A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 8 23 شماره
صفحات -
تاریخ انتشار 2010